• It is noteworthy to mention the limitations

  2023-11-16

  

  It is noteworthy to mention the limitations of this study like tPA plus LB1 treatment beyond 4 h after stroke was not investigated. Especially 6 or 8 h after stroke could be studied in future projects for translational purposes. Second drawback might be that we performed the experiments in different

• br Brain cell reactions Brain cells

  2023-11-16

  

  Brain cell reactions Brain cells in common with all metabolic cells must contain chemically active primary compounds which spontaneously initiate and continue cell reactions under normal conditions of temperature and pressure (NTP). These compounds have been identified as monophosphoric and polyp

• Lee et al have demonstrated that APPL associates

  2023-11-16

  

  Lee et al. have demonstrated that APPL1 associates with AdipoR1 in Hek293 UNC1999 where both proteins have been overexpressed with suitable tags [16]. In contrast to recent data the formation of this complex is not enhanced by exogenous adiponectin [16], [33]. Knock-down of APPL1 reduces the level

• br Acknowledgements This work was supported

  2023-11-16

  

  Acknowledgements This work was supported by the National Key Technology Research and Development Program (2012BAD19B01) and General Financial Grant from the China Postdoctoral Science Foundation (2015M581754). Introduction Cough is one of the most important defensive reflex brought into actio

• NLG919 The small fishers with little or no quota who

  2023-11-16

  

  The small fishers with little or no quota who remained relied on quota leasing arrangements to continue their fishing operations. Such arrangements had relatively high transaction costs and by early 2000 it appeared that the demise of the small fisher was imminent [2]. The introduction in 2001 of t

• The original Aurora kinase was identified

  2023-11-15

  

  The original Aurora kinase was identified during a phenotypic screen for defects in mitotic spindles in Drosophila mutants. Aurora mutants were so named because of the morphological defects at the mitotic spindle resembling the Aurora borealis, or the Northern light [4]. The structure of the Auroras

• Comparison of the GLUT positive plus ACLY negative

  2023-11-15

  

  Comparison of the GLUT1-positive plus ACLY negative group with the GLUT1-negative plus ACLY positive group indicated no significant difference with respect to disease-free survival and overall survival. However, some obvious differences in histological types were found in their formation. A previous

• auda ATM is generally regarded to be the

  2023-11-15

  

  ATM is generally regarded to be the principal mediator of the G1 auda checkpoint, whereas the induction of the intra-S-phase and G2/M checkpoints are usually primarily related to ATR function. However, several studies have demonstrated that, depending on the cellular context and type of DNA damage,

• From an historical perspective ligands for GPCRs adrenaline

  2023-11-15

  

  From an historical perspective, ligands for GPCRs (adrenaline, serotonin, orthopox or morphine, to name a few) have been identified before their receptor counterparts, at a time when the concept of receptor itself was controversial [15]. Although many cognate receptors for endogenous ligands were r

• Co is an essential element

  2023-11-15

  

  Co is an essential element for life in minute amounts [5]. The human adult contains about 1.1mg Co with the daily requirement of 0.1μg/day. Co is a component of vitamin B12. Co induces erythropoietin and blocks iodine uptake by the thyroid, controls the transfer of enzymes like homocysteine methyltr

• Arginases from several species and

  2023-11-15

  

  Arginases from several species and tissues have been found to be inhibited by amino acids [51]. In the present study, monocarboxyilic amino acids with five or more carbon atoms such as ornithine, lysine, valine, leucine and isoleucine inhibited CL-ARG. The results revealed that as the amino Otamixab

• br STAR Methods br Author Contributions br Acknowledgments

  2023-11-15

  

  STAR★Methods Author Contributions Acknowledgments We thank Craig D. Wenger and Neva C. Durand for helpful advice, guidance, and discussions. D.H.P. is supported by the NIH National Human Genome Research Institute (NHGRI) (grant R00HG008662) and the Damon Runyon Cancer Research Foundation (D

• According to the present observations

  2023-11-15

  

  According to the present observations, the Ampkα1 isoform promotes AP-1 transcriptional activity and thereby fosters chemokine receptor of AP-1 target genes in cardiomyocytes via activation of Pkcζ. The transcription factor AP-1 plays a decisive role during cardiac remodeling [24], [25], [26], [37].

• The crucial role of AP

  2023-11-15

  

  The crucial role of AP-1 in establishing and maintaining cell type-specific gene expression programs and cell identity is further apparent during reprogramming of mouse embryo fibroblasts (MEFs) into iPSCs with either Oct4/Sox2/Klf4/cMyc (OSKM ) factors , or chemicals . Using ATAC-seq to profile ch

• br Telmisartan Telmisartan is one of the widely used antihyp

  2023-11-15

  

  Telmisartan Telmisartan is one of the widely used antihypertensive agents, which has demonstrated favorable safety and tolerability profiles, both alone and in combination therapies. It has a number of pharmacological properties that distinguish it from other ARBs—the longest plasma half-life, hi

15354 records 237/1024 page Previous Next First page 上5页 236237238239240 下5页 Last page