• The inhibition of HDAC increases the

  2022-02-05

  

  The inhibition of HDAC increases the level of histone acetylation and consequently turns the chromatin to be loose and active, allowing multiple transcription factors to access to promoters of diverse genes including tumor suppressor genes []. As compound possessed potent HDAC inhibitory activity an

• The gsnor ko plants contain elevated

  2022-02-05

  

  The gsnor-ko plants contain elevated amount of low and high molecular weight S-nitrosothiols (SNO) indicating that GSNOR activity controls the level of both GSNO and indirectly protein-SNOs [13], [17], [18]. GSNOR deficiency has been shown to cause pleiotropic plant growth defects, impaired plant di

• br Advanced Glycation Endproducts As glucose levels rise

  2022-02-04

  

  Advanced Glycation Endproducts As glucose levels rise within sensory neurons as a result of hyperglycemia, normal metabolic pathways become overwhelmed and excess glucose is shunted into other ancillary pathways that, under these conditions, become damaging. One consequence of hyperglycemia is th

• Sensitivity to EphB TKI was also demonstrated in a

  2022-02-03

  

  Sensitivity to EphB3 TKI was also demonstrated in a colon cancer cell line, COLO 205, with high expression of EphB3. We found not only exogenous but also endogenous EphB3 protein was expressed in the COLO 205 fura 2 after transient transfection of pCMV6-AC-GFP/EphB3, and both were demonstrated to b

• br Introduction The brain contains abundant

  2022-02-03

  

  Introduction The brain contains abundant fatty acids, which serve as constituents of membranes and as an energy source. In addition, fatty acids and their metabolites contribute to signal transduction between neurons or neurons and glial cells, suggesting that fatty acids play a crucial role in d

• Another lever to efficiently eradicate

  2022-02-03

  

  Another lever to efficiently eradicate tumors including ovarian cancer might rely on their high addiction to iron [34]. In fact, ultrasmall silica-based nanoparticles, functionalized with melanoma-targeting peptide, efficiently triggered ferroptosis not only in cell culture but also in tumor bearing

• br Declarations of interest br Founding information This wor

  2022-02-03

  

  Declarations of interest Founding information This work was partially supported by the New Energy and Industrial Technology Development Organization (NEDO) Japan [grant number P03043]; and Grants-in-Aid for Scientific Research [grant number 16H00738 to H.M.] from the Japan Society for the Prom

• Before discovery of their histone demethylase

  2022-02-01

  

  Before discovery of their histone demethylase function, the JARID1 isoforms were identified across diverse fields including stem cell biology and congenital disease, as detailed in Box 2. Their observed roles in cancer progression and therapy resistance have led to ongoing pursuit of inhibitors tail

• Concerning GST we could appreciate that when snails

  2022-02-01

  

  Concerning GST, we could appreciate that when snails were exposed to the chosen concentrations of chlorpyrifos, the activity was not modified. According to this result, Kristoff et al. (2008) and Domingues et al. (2007) showed no effects on GST in B. glabrata and L. variegatus exposed to azinphos-me

• Here we demonstrate an anti inflammatory and anticancer func

  2022-02-01

  

  Here we demonstrate an anti-inflammatory and anticancer function for Gpr109a in colon. Gpr109a signaling imposed anti-inflammatory properties in colonic antigen-presenting cells, which in turn induced differentiation of Treg hcv protease inhibitors and IL-10-producing T cells. Gpr109a was also requ

• br Phylogenetic analysis of vertebrate receptors for peptide

  2022-01-31

  

  Phylogenetic analysis of vertebrate receptors for peptides similar to glucagon Genes for receptors for peptides similar to glucagon and other secretin-like hormones have been identified in a number of vertebrate species (Sivarajah et al., 2001, Chow et al., 2004, Irwin and Wong, 2005, Cardoso et

• In the small intestine digestion and absorption

  2022-01-31

  

  In the small intestine, digestion and PKR Inhibitor receptor of the nutrients are the next processes with an impact on the resulting plasma profile. Normally, neither carbohydrate digestion nor absorption are limiting factors, which is illustrated by the rapid and extensive absorption of glucose in

• Thus this work aims to evaluate the effect of tannic

  2022-01-31

  

  Thus, this work aims to evaluate the effect of tannic nociceptin receptor on β-galactosidase activity, by observing the variations in the molecular interaction kinetic parameters ( and ). Besides, these data were correlated with the modifications that the tannin caused to the enzyme’s secondary str

• While earlier reports on ferroptosis did

  2022-01-31

  

  While earlier reports on ferroptosis did not clarify mitochondrial damage and consequent death signaling in this paradigm of oxidative death, evidence from recent studies in neuronal systems strongly suggested a mechanistic link between enhanced lipid peroxide formation and loss of mitochondrial int

• br Results and discussion CATALYST software

  2022-01-31

  

  Results and discussion CATALYST software allows automatic pharmacophore construction by using a collection of molecules with activities ranging over a number of orders of magnitude. In addition, CATALYST pharmacophores (hypotheses) explain the variability of bioactivity with respect to the geomet

15356 records 478/1024 page Previous Next First page 上5页 476477478479480 下5页 Last page