• DNA repair is essential for

  2021-12-29

  

  DNA repair is essential for cell survival and for tissue homeostasis given that cellular DNA is constantly challenged by various endogenous and exogenous genotoxic factors that generate DNA damage: structural and chemical modifications of a primary DNA sequence. Various organisms have evolved multip

• The dopamine substrate currents IDA IControl were determined

  2021-12-29

  

  The dopamine substrate currents (IDA – IControl) were determined at different holding potentials (IV curves) in transfected HT22 cells (Fig. 5A). The plot for HT22 cells transfected with DAT exhibited the typical behavior of dopamine transporter currents (Ingram et al., 2002; Sonders et al., 1997),

• The dopamine substrate currents IDA IControl were determined

  2021-12-29

  

  The dopamine substrate currents (IDA – IControl) were determined at different holding potentials (IV curves) in transfected HT22 cells (Fig. 5A). The plot for HT22 cells transfected with DAT exhibited the typical behavior of dopamine transporter currents (Ingram et al., 2002; Sonders et al., 1997),

• A number of GCK activators for treating

  2021-12-29

  

  A number of GCK activators for treating T2D have been developed and tested but not progressed successfully from clinical trials into therapy [45]. Our observations suggest that increased risk of hypoglycemia might be possible, particularly if drugs penetrate into brain. A further possibility is that

• br Materials and methods br Results br Discussion

  2021-12-28

  

  Materials and methods Results Discussion Acknowledgments This work was financially supported by the University of Tehran, Iran. The authors thank all the teams who worked on the experiments and who provided technical assistance in the laboratory during this study. We also thank the anony

• br Introduction Farnesoid X receptor FXR is

  2021-12-28

  

  Introduction Farnesoid X receptor (FXR) is a bile Etomoxir australia regulated nuclear receptor highly expressed in the liver, intestine, kidney and adrenal glands in rodents.1, 2, 3, 4 FXR regulates transport proteins, the bile salt export pump (BSEP) and the organic solute transporter α (OSTα)

• Our biological data also showed

  2021-12-28

  

  Our biological data also showed that, in presence of LEDGF/p75, R or S of glycerol T instead of T4, T8 or T12 loop in the T30695-GQ differently affected the integration activity of the enzyme (Table 2), whereas the position but not the chirality of glycerol T affected the inhibitory efficiency of T3

• br Introduction Histamine was generally accepted as a neurot

  2021-12-28

  

  Introduction Histamine was generally accepted as a neurotransmitter in 1984, when histamine was first identified to be located in tuberomamillary nucleus (TM) of the brain (Watanabe et al., 1984). In mammals, histaminergic neurons play an important role in regulating multiple physiological activi

• Most hexokinases are widely expressed but distinct hexokinas

  2021-12-28

  

  Most hexokinases are widely expressed but distinct hexokinases predominate specific tissues (Katzen and Schimke, 1965, Rogers et al., 1975). Hexokinase I is found in all mammalian tissues, but is most abundant in the 4-aminopyridine receptor and kidney (griffin et al., 1992). Hexokinase II is the p

• Despite the similarities there are some differences between

  2021-12-28

  

  Despite the similarities, there are some differences between the augmentation by hypoxia and that by thymoquinone. While in porcine coronary arteries they both depend on calcium sensitization mediated by ROCK12, 32, 33, L-type calcium channels are involved only in thymoquinone-induced augmentation.

• br Molecular mechanisms underpinning GSNOR function in the d

  2021-12-28

  

  Molecular mechanisms underpinning GSNOR1 function in the defence response Recently, Arabidopsis GSNOR1 has been shown to govern the extent of S-nitrosylation of two key regulatory proteins, Non-Expresser of Pathogenesis-Related Genes 1 (NPR1) and SA binding protein 3 (SABP3), which are integral t

• Various inhibitors have been developed to

  2021-12-28

  

  Various inhibitors have been developed to target molecules present in these pathways. They include both man-made monoclonal E-4031 australia as well as small molecule membrane permeable inhibitors that often target kinases or phosphatases [5], [338], [348], [364]. In summary, these pathways are fre

• One important aspect about GSK inhibitors

  2021-12-28

  

  One important aspect about GSK-3 inhibitors is their effect on pluripotency of M344 [4]. Many GSK-3 inhibitors are ATP-competitive and suppress both GSK-3alpha and GSK-3beta [476]. BIO was shown to suppress GSK-3 activity and promote Wnt/beta-catenin signaling. This combination of events preserved

• br Materials and methods br Results br Discussion ENU

  2021-12-28

  

  Materials and methods Results Discussion ENU mutagenesis is a powerful approach to identify novel genes or α-Naphthoflavone to dissect the molecular basis of mammalian immune system (Siggs, 2014). T cells are critical components in the host defense against pathogens, and their activity has

• GnRH receptor GnRH R levels are elevated in

  2021-12-28

  

  GnRH receptor (GnRH-R) levels are elevated in decidualized stromal cells, suggesting a function for the GnRH–GnRH-R pathway in the early implantation events. Both GnRH and GnRH-R have been shown to be present in preimplantation embryos and the fallopian tubes at both mRNA and protein levels (). Two

15355 records 499/1024 page Previous Next First page 上5页 496497498499500 下5页 Last page