• br Introduction Nausea and vomiting are among the

  2024-11-09

  

  Introduction Nausea and vomiting are among the most distressing side effects associated with chemotherapy in cancer patients (Billio et al., 2010). Severe emesis can negatively affect a patient's nutritional state, ability to work and motivation, which can, in turn, interfere with the clinical co

• br STAR Methods br Author

  2024-11-09

  

  STAR★Methods Author Contributions Acknowledgments We thank Antony M. Dean for initial discussions and encouragement concerning ancestral sequence reconstruction. We also thank Natalie K. Goto for constructive criticism concerning the manuscript, Steven M. Sine for providing Gemcitabine rec

• Introduction Dementia is a common

  2024-11-09

  

  Introduction Dementia is a common disease in the elderly, and a significant source of disability, healthcare spending, and long-term care admissions. There is evidence to suggest that testosterone plays a role in cognitive functioning, and lower serum levels correlate with higher amyloid deposits (

• In considering the roles of these

  2024-11-09

  

  In considering the roles of these enzymes in normal physiology, given the importance of GLUT4-dependent glucose uptake and glucose-dependent fatty ITSA1 synthesis synthesis for systemic metabolic homeostasis (Herman and Kahn, 2006, Herman et al., 2012), deletion of Acly in adipocytes results in a s

• From an historical perspective ligands for GPCRs adrenaline

  2024-11-09

  

  From an historical perspective, ligands for GPCRs (adrenaline, serotonin, Meropenem or morphine, to name a few) have been identified before their receptor counterparts, at a time when the concept of receptor itself was controversial [15]. Although many cognate receptors for endogenous ligands were

• br Introduction Humans have consumed mushrooms

  2024-11-09

  

  Introduction Humans have consumed mushrooms for centuries because of their high nutrient content and low lipid content, as well as their excellent flavor and texture [1]. Edible mushrooms possess notable medicinal properties and bioactivities, including antitumor, antiviral, antidiabetic, and ant

• Previous studies have thus demonstrated that AR activation g

  2024-11-08

  

  Previous studies have thus demonstrated that AR activation generally correlates with the promotion of urothelial carcinogenesis and cancer growth. In this article, we review available data suggesting their modulation through the AR pathway as well as correlations of AR signals with sensitivity to co

• For the first series we decided to

  2024-11-08

  

  For the first series we decided to verify the effects induced, on the ALR2 inhibitory properties, of an additional steric hindrance on the carbon in α position with respect to the carboxylic group, by introducing a methyl group (R2=Me). Therefore, we synthesized a series of new α-alanine derivatives

• br Experimental procedures Adk tg Adktm tg UbiAdk mice were

  2024-11-08

  

  Experimental procedures Adk-tg (Adktm1−/−:tg(UbiAdk) mice were created by breeding a loxP-flanked Adk transgene under the control of a human ubiquitin promoter into ADK knockout mice (Fedele et al., 2005,). Fb-Adk-def (Adktm1−/−:tg(UbiAdk):Emx1-Cre-tg3) mice were generated by pairing Emx1-Cre-tg3

• Indanone and its analogues are useful

  2024-11-08

  

  1-Indanone and its analogues are useful intermediates for the synthesis of compounds some of which have applications as pharmaceuticals, especially as analgesic and antihypertensive as well as tobacco flavoring agents. Indanones are commonly used as starting agent for the synthesis of ninhydrin whic

• Additionally regulation of GPCR heteromerization

  2024-11-08

  

  Additionally, regulation of GPCR heteromerization by specific ligands may depend not only on the affinity of ligands for receptors, but also on presence of different interacting proteins co-localizing with the receptors in the specific cell, which may induce some conformational changes and contribut

• Pyrimidine is the important pharmacology core in

  2024-11-07

  

  Pyrimidine is the important pharmacology core in many Aurora inhibitors, such as VX-680, ENMD-2076, CYC-116 and ENMD-2076 [12]. To identify additional effective Aurora inhibitors, we designed a series of 2,4-diaminopyrimidine compounds, our modeling studies suggested that the HAT Inhibitor II synthe

• Although plant Aurora kinases can be clearly grouped into fu

  2024-11-07

  

  Although plant Aurora kinases can be clearly grouped into functional clades, the roles of the respective clades does not seem to be evolutionarily conserved. AtAurora 1 labels kinetochore microtubules [19], similarly to mammalian Aurora A, while its targeting to the cell plate resembles features of

• Here we report discovery of highly selective

  2024-11-07

  

  Here we report discovery of highly selective pan-Aurora kinase inhibitors through phenotypic screening. The co-crystal structure of Go 6983 synthesis bound in the ATP binding site of Aurora A is described, and provides insight into the possible structural basis for the selectivity of the interacti

• In this study we observed the ATPase activity of

  2024-11-07

  

  In this study, we observed the ATPase activity of RaGroEL at various temperatures and metal ions conditions and the role of GroES in the ATPase activity of RaGroEL. Furthermore, we quantified the expression of groEL genes under different abiotic stresses, including temperature, pH, salt and oxygen s

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