• Our study found a significant association between the degree

  2019-10-01

  

  Our study found a significant association between the degree of primary tumor lobulation and EGFR mutations status (P SCH 58261 clinical status. However, only a small portion of these previous studies included the evaluation of lobulation, and almost all of them reported no association between EGFR

• br Materials and methods br Results br Discussion Anti

  2019-10-01

  

  Materials and methods Results Discussion Anti-EGFR therapy for epithelial carcinomas has important clinical significance, but widespread intrinsic or acquired resistance seriously affects efficacy. Mutation and heterodimerization of EGFR are the two main causes of resistance to anti-EGFR th

• A prominent example of such

  2019-10-01

  

  A prominent example of such enzyme is the proteasome, a highly promising target not only in cancer, but also in inflammatory and autoimmune diseases. Circulating proteasomes and respective anti-proteasome autoantibodies were detected in serum samples from patients with autoimmune diseases such as mu

• We aim to apply the same technology

  2019-10-01

  

  We aim to apply the same technology to target other collagen-binding proteins using motifs from collagens that are specific for other receptors or matrix components. Previously, we synthesized THP libraries, called Toolkits, composed of an active guest sequence flanked by five GPP host triplets that

• Although the phase I clinical trial of LMB was unsuccessful

  2019-10-01

  

  Although the phase I clinical trial of LMB was unsuccessful, the detailed review of this trial only mentions some malaise and anorexia as side effects, which are common for most effective chemotherapeutic drugs. These side effects may diminish if lower doses are administered. In view of the novel CR

• Transduction of cellular signals by G protein coupled recept

  2019-10-01

  

  Transduction of cellular signals by G protein-coupled receptors (GPCRs) is stringently regulated to prevent the deleterious effects of unrestrained GPCR signaling. The rapid termination of signaling mediated by agonist-occupied GPCRs is referred to as homologous desensitization and involves the foll

• Among the various neurotransmitter systems

  2019-10-01

  

  Among the various neurotransmitter systems pointed out to play a role in the mediation of defensive and antinociceptive responses elicited by environmentally aversive stimuli, the neuropeptide corticotropin-releasing factor or hormone (CRF or CRH) has attracted the interest of many researchers inves

• Epigenetic silencing of genes that determine tumor

  2019-10-01

  

  Epigenetic silencing of genes that determine tumor invasiveness, growth patterns of tumors, and tumor-cell apoptosis12, 29 may also affect the expression of drug-metabolizing enzymes, thereby providing an additional genetic mechanism in pharmacogenomics. Trisomy 8 that contains wild-type GGH could b

• br Experimental br Declaration of interest br Introduction b

  2019-10-01

  

  Experimental Declaration of interest Introduction Material and methods Results and discussion Conclusion By screening the NMR Fmoc-Ser(tBu)-OH and library an initial hit was found for an inhibitor of the PPI between the α-β subunits of CK2 with an IC50 of 900 μM. This compound was

• In the context of our ongoing

  2019-10-01

  

  In the context of our ongoing studies to define the phytochemical and biological properties of oxyprenylated secondary metabolites of plant and fungal origin, we wish to report herein the investigation on the interaction of some natural and semisynthetic O-alkylcoumarins with promising ChE inhibitor

• Considering these reports and with the aim of further

  2019-10-01

  

  Considering these reports, and with the aim of further investigating the mechanism by which the cAMP-Epac/PKA pathway activates eNOS, we have performed imaging experiments evaluating the effect of drugs that increase cAMP or modify its signalling pathways (PKA or Epac activators and inhibitors) on b

• br A brief history of RBR E s RBR

  2019-10-01

  

  A brief history of RBR E3s RBR E3s were originally defined based on sequence alignments that predicted a tripartite motif of three zinc (Zn)-binding domains: two RING domains (RING1 and RING2) connected via an in-between-RING (IBR) domain [28], [29]. The prediction together with initial observati

• One of the most fundamental distinctions between

  2019-10-01

  

  One of the most fundamental distinctions between Ub signals is substrate monoubiquitination versus polyubiquitination. With the exception of the E2, UBE2W, which represents a special case because it RHPS4 pathway only ubiquitinates the flexible N-termini of substrates [5], [6], [20], most examples o

• br Results br Discussion Taking advantage

  2019-10-01

  

  Results Discussion Taking advantage of the highly specific protein–protein interactions among cognate GSK481 that mediate SUMO conjugation to substrates, we have developed a novel strategy for achieving inhibition of SUMO conjugation in vivo based on disruption of SUMO E1–E2 interactions. We h

• br Materials and methods br Results br Discussion Regardless

  2019-10-01

  

  Materials and methods Results Discussion Regardless of obvious beneficial effects of GC on acceleration of foetal lung and cardiomyocytes maturation (Kamath-Rayne et al., 2012; Rog-Zielinska et al., 2015), the current study revealed that GC exposure during late pregnancy induces IR and alte

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